World-Wide Praise for Colloidal Silver from Clinical Researchers
Clinical research experts worldwide are singing the praises of colloidal silver, silver ions, silver nanoparticles and other forms of antimicrobial silver.
Only in the U.S. are medical authorities still clinging to the Big Pharma-inspired notion that silver is “ineffective” or “obsolete.”
Indeed, many cutting edge clinical researchers from around the world are beginning to admit that colloidal silver and other forms of antimicrobial silver might just be the answer to the worldwide crisis of antibiotic-resistant super-bugs, hospital infections, and other serious problems.
Let’s take a quick look at what some of these researchers are saying…
At this link you can find over 100 clinical studies, medical white papers and reports on the effectiveness of various forms of silver against disease-causing pathogens and related disease process.
Below you can read short quotes from clinical studies conducted by researchers from around the globe on various forms of silver and their proven effectiveness against pathogens and disease processes.
“All tested bacteria were resistant to more than one antibiotic. The important observation was the antibacterial activity of colloidal silver against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Pseudomonas aeruginosa which exhibits superior effects when compared with other antibiotics.”
– International Journal of Microbiological Research, [1 (1): 33-36, 2010] “Colloidal silver as a new antimicrobial agent,” Department of Microbiology at the National Organization for Drug Control and Research in Giza, Egypt
“Our study has further confirmed the potent antibacterial activity of colloidal silver concentrate against Pseudomonas aeruginosa…In the present study, colloidal silver was shown to demonstrate very potent antibacterial activity against P. aeruginosa isolated from post operative eye infection.
This activity should be urgently explored in the development of highly active antibacterial therapeutic agents to combat the rapidly increasing infectious diseases that currently challenge the present arsenal of antibacterial drugs.”
– Department of Applied Microbiology, Ebonyi State University, Abakaliki, Nigeria, and the Department of Pharmaceutics, University of Nigeria, at Nsukka, Nigeria, “In vitro evaluation of the activity of colloidal silver concentrate against Pseudomonas aeruginosa isolated from postoperative wound infection”
“Hospital-acquired infections are one of the most important causes of complications and mortality in medical centers. These infections have been considered as the sixth leading cause of death in US and Europe. As well, they contribute 10-50 billion dollars to the economic burden annually.
For this reason, we studied the effect of different dilutions of silver nanoparticles on some of the common hospital organisms at specific intervals. Results: All the three dilutions of silver nanoparticles studied had definite positive effects on the bacteria under study…resulting in more than a 99 percent reduction.”
– Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran, “Effect of Silver Nanoparticles on Common Bacteria in Hospital Surfaces”
“Silver ions have long been known to have strong inhibitory and bactericidal effects as well as a broad spectrum of antimicrobial activities. Some forms of silver have been demonstrated to be effective against burns, severe chronic osteomyelitis, urinary tract infections, and central venous catheter infections…
…To investigate the mechanism of inhibition of silver ions on microorganisms, two strains of bacteria, namely Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were treated with silver ions and studied using combined electron microscopy and X-ray microanalysis.
Similar morphological changes occurred in both E. coli and S. aureus cells after silver ion treatment. The cytoplasm membrane detached from the cell wall. A remarkable electron-light region appeared in the center of the cells, which contained condensed deoxyribonucleic acid (DNA) molecules. There are many small electron-dense granules either surrounding the cell wall, or depositing inside the cells.
The existence of elements of silver and sulfur in the electron-dense granules and cytoplasm suggested the antibacterial mechanism of silver: DNA lost its replication ability and the protein became inactivated after the silver ion treatment.”
– Journal of Biomedical Materials Research, Volume 52, Issue 4, 15, “A Mechanistic Study of the Antibacterial Effects of Silver Ions on Escherichia coli and Staphylococcus aureus”; Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
“Scientists have discovered that the body’s most important fluids are colloidal in nature: suspended ultra-fine particles. Blood, for example, carries nutrition and oxygen to the body cells. This led to studies with colloidal silver (electrical silver atoms). An electro-colloidal process, which is known to be the best method, is used for manufacturing the colloidal silver.
Colloidal silver appears to be a powerful, natural antibiotic and preventative against infections. Acting as a catalyst, it disables the enzyme that one-celled bacteria, viruses and fungi need for their oxygen metabolism. They suffocate without corresponding harm occurring to human enzymes or parts of the human body chemistry. The result is the destruction of disease-causing organisms in the body and in the food.”
– Nanotechnology in Medicine and Antibacterial Effect of Silver Nanoparticles, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, published in the Digest Journal of Nanomaterials and Biostructures Vol. 3, No.3, September 2008, p. 115-122
“Recently, due to the emergence of antibiotic-resistant bacteria and the use limitations of antibiotics that can cause serious diseases and is an important public health problem, the synergetic effect of silver nanoparticles with antibiotics has been studied combining silver nanoparticles with different antibiotics like ampicillin, kanamycin, erythromycin and chloramphenicol against gram positive and gram negative bacteria.
The antibacterial activities of these antibiotics increase in the presence of silver nanoparticles against gram positive and gram negative bacteria determined by the disk diffusion method. Different diameters of inhibition zones have been shown around the different antibiotic disk with or without AgNPs.
The combination effect of nanosilver and ampicillin has more potential compared to the other antibiotics and may be caused by both, the cell wall lysis action of the ampicillin and the DNA binding action of the silver nanoparticles (Fayaz et al., 2009).
The antibiotic molecules contain many active groups such as hydroxyl and amido groups, which reacts easily with silver nanoparticles by chelation, for this reason, the synergistic effect may be caused by the bonding reaction with antibiotic and silver nanoparticles.”
– Silver Nanoparticles Interactions with the Immune System: Implications for Health and Disease, CABIMER-Andalusian Center for Molecular Biology & Regenerative Medicine CSIC-University of Seville-UPO-Junta de Andalucia, Seville, Spain 2 Department of Physical, Chemical & Natural Systems, Pablo de Olavide University, Seville, Spain
“The most important finding is that silver-unlike most antibiotics-works in more than one way. This is perhaps why bacteria may find it difficult to build resistance to the chemical. Here is silver’s multi-pronged approach:
First, silver sticks very strongly to sulfur, found in parts of [bacterial] proteins. These sulfur groups normally bond to each other, holding proteins together and keeping the protein folded up in its correct shape. But if silver interacts with sulfur, then the protein cannot fold correctly, and thus it cannot do its job.
Next, silver interferes with how bacteria use iron. Iron is often held in place within proteins by binding to sulfur. Since silver also interacts with sulfur, it blocks the iron from doing so. Finally, silver causes bacteria to produce extremely toxic substances called reactive oxygen species. These go on to cause damage inside the cell, harming the DNA, proteins, and even the membrane that surround cells.
The net result of this silver onslaught is bacteria with severe damage to their basic biochemistry. In addition, the membranes and walls that surround the bacteria are leakier after the silver treatment.”
– Mark Lorch, ARS Technica, Senior Lecturer in Biological Chemistry at University of Hull, UK
“Many studies have shown the antimicrobial effects of nanosilver, but the effects of nanosilver against fungal pathogens of the skin, including clinical isolates of T. mentagrophytes and Candida species are mostly unknown.
The primary significance of this study is the observation that nanosilver can inhibit the growth of dermatophytes, which cause superficial fungal infections. Nanosilver also exhibited potent antifungal effects, probably through destruction of membrane integrity.
To the author’s knowledge, this is the first study to apply nanosilver successfully to dermatophytes and pathogenic fungal strains. Secondly, the fact that preparation method of nanosilver described here is cost-effective is also of importance. Therefore, it can be expected that nanosilver may have potential as an anti-infective agent for human fungal diseases.”
– The Silver Nanoparticle (Nano-Ag): a New Model for Antifungal Agents, Dong Gun Lee School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Republic of Korea
“…It is well known that silver exhibits potent antibacterial properties with low toxicity for humans and animals, by comparison with other metals. Many researchers have recently reported that silver nanoparticles demonstrate excellent antibacterial activity.”
– On-Paper Synthesis of Silver Nanoparticles for Antibacterial Applications, Hirotaka Koga and Takuya Kitaoka, Kyushu University, Japan
“The data presented here prove that silver nanoparticles are effective bactericidal agents regardless of the drug-resistance mechanisms that exist in multidrug-resistant P. aeruginosa, ampicillin-resistant E. coli O157:H7 and erythromycin-resistant S. pyogenes and show the importance of silver nanoparticles in the nosocomial and community environment. Therefore, silver nanoparticles can be recommended as an effective broad-spectrum bactericidal agent.”
– “Bactericidal Effect of Silver Nanoparticles Against Multidrug-Resistant Bacteria,” World Journal of Microbiology, Volume 26, Number 4, 615-621, DOI: 10.1007/s11274-009-0211-3) April 10, 2009
“Silver is non-toxic, safe inorganic antibacterial agent being used for centuries and is capable of killing about 650 microorganisms that cause disease. Silver has been described as being ‘oligodynamic’, that is, its ions are capable of causing a bacteriostatic (growth inhibition) or even a bactericidal (antibacterial) impact.
Therefore, it has the ability to exert a bactericidal effect at minute concentrations.
It has a significant potential for a wide range of biological applications such as antibacterial agents for antibiotic resistant bacteria, preventing infections, healing wounds and anti-inflammatory. Silver ions (Ag+) and its compounds are highly toxic to microorganisms exhibiting strong biocidal effects on many species of bacteria but have a low toxicity toward animal cells.”
– Muhammad Raffi, Synthesis and Characterization of Metal Nanoparticles, Department of Chemical and Materials Engineering, Pakistan Institute of Engineering and Applied Sciences
“Study Synopsis: Sixteen patients with leg ulcers were treated with a colloidal silver spray. The solution was applied once daily for the first few days, then twice weekly. The infection subsided in all cases. After instruction, patients performed the therapy at home without supervision. No discomfort or side effects were observed. There was no persistent discoloration of the skin that could be attributed to silver. “In all cases the infection subsided.”
– Haeger, Knut. Preoperative treatment of leg ulcers with silver spray and aluminum foil. Acta Chirurgica Scandinavica, 125, 32-41.
“…silver particles with a narrow size distribution with an average size of 25 nm showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multi-resistant strains such as methicillin-resistant Staphylococcus aureus.
Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 μg/mL Ag) gave antibacterial performance.”
– Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity; Department of Physical Chemistry, Palacký University, Svobody 26, 771 46 Olomouc, Czech Republic, Department of Microbiology, Faculty of Medicine, Palacký University, Czech Republic
“Silver is a disinfectant for non-spore forming bacteria at concentrations about 1000 times lower than the levels at which it is toxic to mammalian life. …The ionic form of silver is necessary.”
– British Columbia Ministry of Environment, Ambient Water Quality Criteria for Silver, Environmental Protection Department, February 19, 1996
“In the safety study, normal saline (control) and 30ppm colloidal silver solution (test) was used to flush the frontal sinuses for 14 days in 8 sheep (4 sheep each). In the efficacy study, following frontal sinus infection with Staphylococcus aureus, sheep were treated with either control saline or topical silver solution of varying concentrations (30 ppm/20 ppm/10 ppm/5 ppm) for 5 days, with 4 sheep in each group.
Sheep treated with colloidal silver showed a significant decrease in biofilm biomass compared to saline control. Although average blood silver levels were higher in the treated groups compared to controls, blood counts and biochemical parameters were normal. Histology and ciliary structure analysis did not show any difference between control and treatment groups…Conclusion: Topical colloidal silver solution has effective antibiofilm activity in Staphylococcus aureus CRS in a sheep model and appears safe.”
– “Topical colloidal silver as an antibiofilm agent in a Staphylococcus aureus chronic rhinosinusitis sheep model”; International Forum of Allergy & Rhinology; The Queen Elizabeth Hospital, Department of Surgery, University of Adelaide, Adelaide, Australia
“Silver or silver ions have long been known to possess strong inhibitory and bactericidal effects, as well as a broad spectrum of antimicrobial activities…
In this study, the antimicrobial activity of colloidal silver nanoparticles prepared by the Sol-Gen method was investigated [against] test microorganisms Escherichia coli, Staphylococcus aureus, Candida albicans, Bacillus subtilis, Salmonella typhimurium, Pseudomonas aeruginosa and Klebsiella pneumoniae .
It was found that the silver nanoparticles inhibited the growth and multiplication of the tested microorganisms, including the fungus C. albicans. The antimicrobial activity was observed against all tested microorganisms at a very low concentration of 2-4 μg/ml of nano silver.”
– “Antimicrobial Activity Of Colloidal Silver Nanoparticles Prepared By Sol-Gel Method,” Digest Journal of Nanomaterials and Biostructures, Metallurgical and Material Science Engineering Department at Dokuz Eylul University, Turkey
“Previously, we reported the cytotoxic effect of colloidal silver on MCF-7 breast cancer cell line. However, there is scarce information on its antitumor potential. The aim of this study was to evaluate the anti-tumoral activity of colloidal silver or silver nanoparticles (AgNPs) in a B16F10 melanoma mice model.
In vitro, B16F10 cells were treated with different concentrations of colloidal silver or silver nanoparticles and cell viability was evaluated by MTT method, both treatments had cytotoxic effects against B16F10 cell line. In vivo, B16F10 melanoma cells were implanted in six weeks old C57BL/6 mice.
About 8 days after cells injection, the subcutaneous treatments were started with colloidal silver or silver nanoparticles, tumor volume and tumor weight were evaluated and the difference of treated groups and control demonstrated that melanoma tumor growth was significantly decreased. Our results suggest that colloidal silver or silver nanoparticles could be useful as an anti-proliferative drug, inducing an impairment of tumoral growth.”
– African Journal of Microbiology Research, May 2013, “Potential of colloidal or silver nanoparticles to reduce the growth of B16F10 melanoma tumors”
Much, Much More
Frankly, I could post excerpts from a wide variety of international clinical studies like these all day. There are literally hundreds of them available.
But hopefully the examples above have given you enough detail to see that researchers from around the world are finding colloidal silver and other forms of antimicrobial silver to be astonishingly effective against infectious microorganisms, as well as other disease processes including cancer.
In the future, I’ll post more examples. But feel free to browse through the wide array of silver studies posted here.